PATHOPHYSIOLOGY OF PANCYTOPENIA: UNDERSTANDING BLOOD CELL PRODUCTION AND REGULATION IN THE BONE MARROW

Objective: The bone marrow is the primary site for blood cell formation, responsible production and export of red cells, platelets, granulocytes. Pancytopenia a condition characterized by reduction in all three types cellular components peripheral blood, leading to symptoms failure. management prognosis pancytopenia depend on identifying underlying pathology.
 Methods: pathophysiology involves various factors such as infections, toxins, malignant infiltration, suppression, or ineffective hematopoiesis. Bone examination, including aspiration trephine biopsy, crucial diagnosing pancytopenia, especially when cause unclear malignancy suspected. Geographic distribution genetic disturbances contribute variations incidence disorders causing pancytopenia.
 Results: study aims evaluate causes correlate findings with aspirate biopsy. collected data will assist planning diagnostic therapeutic approach patients Conclusion: disruptions regulation. biopsy are diagnosis. Understanding regulation provides insights. This enhance approaches pancytopenia.